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MTHFR Pediatric Dental Anesthesia Warning

Epigenetic mutation of MTHFR  gene.

The new science of epigenetics helps explain many health and medical mysteries of the recent century. Recent research has revealed a potentially life threatening reaction to Nitrous Oxide dental anesthesia by children with an epigenetic mutation of the MTHFR, or Methylene Tetrahydrofolate Reductase, gene that produces an enzyme by the same name.    

Children with MTHFR, or Methylene Tetrahydrofolate Reductase, deficiency may be at risk for a serious and potentially life threatening reaction to Nitrous Oxide anesthesia. Commonly used for pediatric dental and some other medical procedures that require a child be calm and still, Nitrous Oxide has been demonstrated to deactivate B12 in children with a mutation of the MTHFR gene that produces the MTHFR enzyme. When the mutation, also called polymorphism, results in a deficiency of the MTHFR enzyme, children can suffer serious harm from this interference with B12.



Download this free White Paper that explains the research and science from around the world explaining this alarming phenomenon:

Methylene Tetrahydrofolate Reductase Deficiency


Dr. Darleen Claire Wodzenski is a Child Development and Special Education Interventionist, Clinical Mental Health Counselor, and Non-Clinical Psychoneuroeducational Psychologist. Her areas of focus include promoting Attachment Development in children with Attachment Disorders including RAD and DSED; and promoting Social and Emotional Development of Children who are Neuro-Atypical or with Neurodevelopmental, Autism Spectrum, and other disorders.


Contact Dr. Darleen Claire at or call (770) 686-0894